Question 1

2022

Accepted Answer

Wang, Weihong, et al. "Flavonoid Glycosides from Ulmus macrocarpa Inhibit Osteoclast Differentiation via the Downregulation of NFATc1." ACS omega 7.6 (2022): 4840-4849.
Hahn, Dongyup, et al. "Determination of sequence and absolute configuration of peptide amino acids by HPLC–MS/CD-based detection of liberated N-terminus phenylthiohydantoin amino acids." Scientific reports 12.1 (2022): 1-10.
Oh, Eunseok, et al. "(+)-Usnic acid and its salts, inhibitors of SARS‐CoV‐2, identified by using in silico methods and in vitro assay." Scientific Reports 12.1 (2022): 1-10.

Question 2

2021

Accepted Answer

Kim, K. J., et al. (2021). "Austalide K from the Fungus Penicillium rudallense Prevents LPS-Induced Bone Loss in Mice by Inhibiting Osteoclast Differentiation and Promoting Osteoblast Differentiation." Int J Mol Sci 22(11).
Kim, H., et al. (2021). "Antibacterial Bicyclic Fatty Acids from a Korean Colonial Tunicate Didemnum sp." Mar Drugs 19(9).

Question 3

2020

Accepted Answer

Wang, W., et al. (2020). "A New Thiopeptide Antibiotic, Micrococcin P3, from a Marine-Derived Strain of the Bacterium Bacillus stratosphericus." Molecules 25(19).

Question 4

2019

Accepted Answer

W.H. Wang, et al. (2019) “Austalides, Osteoclast Differentiation Inhibitors from a Marine-Derived Strain of the Fungus Penicillium rudallense” J. Nat. Prod
J.H. Lee, et al. (2019) "Mycousfurans A and B, Antibacterial Usnic Acid Congeners from the Fungus Mycosphaerella sp., Isolated from a Marine Sediment" Marine Drugs
Thi Hanh Nguyen Vu, et al. (2019) "Endophytic actinomycetes associated with Cinnamomum cassia Presl in Hoa Binh province, Vietnam: Distribution, antimicrobial activity and, genetic features" The Journal of General and Applied Microbiology
W.H. Wang, et al. (2019) "Benzophenone Compounds, from a Marine-Derived Strain of the Fungus Pestalotiopsis neglecta, Inhibit Proliferation of Pancreatic Cancer Cells by Targeting the MEK/ERK Pathway" J. Nat. Prod

Question 5

2018

Accepted Answer

Kim, D. S., et al. (2018). "Synthesis and evaluation of an orally available "Y"-shaped biaryl peroxisome proliferator-activated receptor delta agonist." Bioorg Med Chem.
Yang, I., et al. (2018). "Scalalactams A(-)D, Scalarane Sesterterpenes with a gamma-Lactam Moiety from a Korean Spongia Sp. Marine Sponge." Molecules 23(12).

Question 6

2017

Accepted Answer

Yim, C. Y., et al. (2017). "Saccharomonopyrones A-C, New alpha-Pyrones from a Marine Sediment-Derived Bacterium Saccharomonospora sp. CNQ-490." Mar Drugs 15(8)
Chin, J. W., et al. (2017). "Regioselective Synthesis of the FXR Antagonist E‐Guggulsterone from Three Natural Steroids." Bulletin of the Korean Chemical Society 38(5) 
Wang, W., et al. (2017). "Cadiolides J-M, antibacterial polyphenyl butenolides from the Korean tunicate Pseudodistoma antinboja." Bioorg Med Chem Lett 27(3): 574-577.

Question 7

2016

Accepted Answer

Yeon, J. T., et al. (2016). "Acredinone C and the Effect of Acredinones on Osteoclastogenic and Osteoblastogenic Activity." J Nat Prod 79(7): 1730-1736.
Lee, J., et al. (2016). "Marinopyrones A–D, α-pyrones from marine-derived actinomycetes of the family Nocardiopsaceae." Tetrahedron Letters 57(18): 1997-2000.
Hahn, D., et al. (2016). "The Halicylindramides, Farnesoid X Receptor Antagonizing Depsipeptides from a Petrosia sp. Marine Sponge Collected in Korea." J Nat Prod 79(3): 499-506.

Question 8

2015

Accepted Answer

Hahn D.Y., et al. (2015). "A Novel Bromoindole Alkaloid from a Korean Colonial Tunicate Didemnum sp." Natural Product Sciences 21(4): 278-281.
Yang I.H., et al. (2015). "Two New Scalaranes from a Korean Marine Sponge Spongia sp." Natural Product Sciences 21(4): 289-292.
Yang I.H., et al. (2015). "A new 9, 11-secosterol with a 1, 4-quinone from a Korean marine sponge Ircinia sp." Archives of pharmacal research 38(11): 1970-1974.
Leutou, A. S., et al. (2015). "Nocarimidazoles A and B from a Marine-Derived Actinomycete of the Genus Nocardiopsis." J Nat Prod 78(11): 2846-2849.
Lee, H. W., et al. (2015). "Inhibition of Monoamine Oxidase by Anithiactins from Streptomyces sp." J Microbiol Biotechnol 25(9): 1425-1428. 
Yang I.H., et al. (2015). "Two Indole‐Alkaloids from a Korean Marine Sponge Spongia sp." Bulletin of the Korean Chemical Society 36(8) : 2120-2123.
Kim, H., et al. (2015). "Acredinones A and B, voltage-dependent potassium channel inhibitors from the sponge-derived fungus Acremonium sp. F9A015." J Nat Prod 78(3): 363-367.
Mun. B., et al. (2015). "Cytotoxic 5α, 8α-epidioxy sterols from the marine sponge Monanchora sp." Archives of pharmacal research 38(1): 18-25.

Question 9

2014

Accepted Answer

Wang, W., et al. (2015). "Monanchosterols A and B, bioactive bicyclo[4.3.1]steroids from a Korean sponge Monanchora sp." J Nat Prod 78(3): 368-373.
Kim, H., et al. (2014). "Anithiactins A-C, modified 2-phenylthiazoles from a mudflat-derived Streptomyces sp." J Nat Prod 77(12): 2716-2719.
Lee, Y., et al. (2014). "Phorbaketals L-N, cytotoxic sesterterpenoids isolated from the marine sponge of the genus Phorbas." Bioorg Med Chem Lett 24(17): 4095-4098.
Hahn, D., et al. (2014). "Sesquiterpenoids with PPARδ agonistic effect from a Korean marine sponge Ircinia sp." Tetrahedron Letters 55(34): 4716-4719
Lee, J., et al. (2014). "Anmindenols A and B, inducible nitric oxide synthase inhibitors from a marine-derived Streptomyces sp." J Nat Prod 77(6): 1528-1531.
Kim, H., et al. (2014). "Placotylene A, an inhibitor of the receptor activator of nuclear factor-kappaB ligand-induced osteoclast differentiation, from a Korean sponge Placospongia sp." Mar Drugs 12(4): 2054-2065. 
Yang, I., et al. (2014). "An antibacterial 9, 11-secosterol from a marine sponge Ircinia sp."  Bulletin of the Korean Chemical Society 35(11): 3360-3362.

Question 10

2013

Accepted Answer

Hahn, D., et al. (2013). "Cytotoxic scalarane sesterterpenes from a Korean marine sponge Psammocinia sp." Bioorg Med Chem Lett 23(8): 2336-2339.
Wang, W., et al. (2013). "Bioactive sesterterpenoids from a Korean sponge Monanchora sp." J Nat Prod 76(2): 170-177.

Question 11

2012

Accepted Answer

Kim, H., et al. (2013). "Phosphoiodyns A and B, unique phosphorus-containing iodinated polyacetylenes from a Korean sponge Placospongia sp." Org Lett 15(1): 100-103.
Wang, W., et al. (2012). "Antibacterial butenolides from the Korean tunicate Pseudodistoma antinboja." J Nat Prod 75(12): 2049-2054.
Wang, W., et al. (2012). "Phorone A and isophorbasone A, sesterterpenoids isolated from the marine sponge Phorbas sp." Org Lett 14(17): 4486-4489.
Ham, J., et al. (2012). "Discovery, design and synthesis of Y-shaped peroxisome proliferator-activated receptor delta agonists as potent anti-obesity agents in vivo." Eur J Med Chem 53: 190-202.
Shin, K., et al. (2012). "Sterols from a soft coral, Dendronephthya gigantea as farnesoid X-activated receptor antagonists." Steroids 77(5): 355-359.

Question 12

2011

Accepted Answer

J. Ham., et al. (2011). "A regioselective of E-guggulsterone" Molecules 16(5): 4165-4171.
H. J. Park., et al. (2011). "Synthesis of an unnatural steroid as a farnesoid X receptor antagonist" Bulletin of the Korean Chemical Society 32(12): 4165-4166.

Question 13

2010

Accepted Answer

Choi, H., et al. (2010). "Tuberatolides, potent FXR antagonists from the Korean marine tunicate Botryllus tuberatus." J Nat Prod 74(1): 90-94.
Chin, J., et al. (2010). "Selective peroxisome proliferator-activated receptor delta isosteric selenium agonists as potent anti-atherogenic agents in vivo." Bioorg Med Chem Lett 20(24): 7239-7242.
Ko, J., et al. (2010). "A stereo-controlled synthesis of 2,4-dimethyl-4-hydroxy-16-phenylhexadecanoic acid 1,4-lactone and its PPAR activities." Bioorg Med Chem Lett 20(20): 6017-6019.
Jang, K. P., et al. (2010). "7-Phenylplatensimycin and 11-methyl-7-phenylplatensimycin: more potent analogs of platensimycin." Bioorg Med Chem Lett 20(7): 2156-2158. 
Oh, K., et al. (2010). "A receptor-independent, cell-based JAK activation assay for screening for JAK3-specific inhibitors." J Immunol Methods 354(1-2): 45-52.
Park, S. Y., et al. (2010). "Gukulenins A and B, cytotoxic tetraterpenoids from the marine sponge Phorbas gukulensis." J Nat Prod 73(4): 734-737.

Question 14

2009

Accepted Answer

Jang, K. P., et al. (2009). "Isoplatensimycin: Synthesis and biological evaluation." Bioorg Med Chem Lett 19(16): 4601-4602.
Ahn, H. R., et al. (2009). "A facile one-pot preparation of organoselanyltrifluoroborates from dihalobenzenes and their cross-coupling reaction." Org Lett 11(2): 361-364.

Question 15

2008

Accepted Answer

Narkar, V. A., et al. (2008). "AMPK and PPARdelta agonists are exercise mimetics." Cell 134(3): 405-415. 
Choi, H., et al. (2008). "Cyanopeptoline CB071: a cyclic depsipeptide isolated from the freshwater cyanobacterium Aphanocapsa sp." Chem Pharm Bull (Tokyo) 56(8): 1191-1193.
Park, Y. H., et al. (2008). "A facile one-pot preparation of potassium hydroxyaryl- and (hydroxyalkyl)aryltrifluoroborates." Org Lett 10(6): 1215-1218. 
Barish, G. D., et al. (2008). "PPARdelta regulates multiple proinflammatory pathways to suppress atherosclerosis." Proc Natl Acad Sci U S A 105(11): 4271-4276.
Hyun, Y., et al. (2008). "Cooperation and functional diversification of two closely related galactolipase genes for jasmonate biosynthesis." Dev Cell 14(2): 183-192. 
Wang, W., et al. (2008). "Beta-carboline alkaloids from a Korean tunicate Eudistoma sp." J Nat Prod 71(2): 163-166.

Question 16

2007

Accepted Answer

Nam, S. J., et al. (2007). "Scalarane sesterterpenes from a marine sponge of the genus Spongia and their FXR antagonistic activity." J Nat Prod 70(11): 1691-1695.

Question 17

2006

Accepted Answer

Nam, S. J., et al. (2006). "Farnesoid X-activated receptor antagonists from a marine sponge Spongia sp." Bioorg Med Chem Lett 16(20): 5398-5402.
Ko, J. Y., et al. (2006). "A simple one-pot synthesis of hydroxylated and carboxylated aryl alkyl sulfides from various bromobenzenes" Tetrahedron letters 47(39): 7101-7106.
Ham, J., et al. (2006). "A facile one-pot preparation of alkyl aminoaryl sulfides for the synthesis of GW7647 as an agonist of peroxisome proliferator-activated receptor alpha." J Org Chem 71(15): 5781-5784.
Lee, C. H., et al. (2006). "PPARdelta regulates glucose metabolism and insulin sensitivity." Proc Natl Acad Sci U S A 103(9): 3444-3449.

Question 18

2005

Accepted Answer

Ham, J. Y., et al. (2006). "A highly efficient synthesis of antiobestic ligand GW501516 for the peroxisome proliferator-activated receptor δ through in situ protection of the phenol group by reaction with a Grignard reagent" Tetrahedron letters 46(39): 6683-6686.
Park, Y. Y., et al. (2005). "An autoregulatory loop controlling orphan nuclear receptor DAX-1 gene expression by orphan nuclear receptor ERRgamma." Nucleic Acids Res 33(21): 6756-6768.

Question 19

2004

Accepted Answer

Wang, Y. X., et al. (2004). "Regulation of muscle fiber type and running endurance by PPARdelta." PLoS Biol 2(10): e294.
Ham, J., et al. (2004). "A facile one-pot synthesis of alkyl aryl sulfides from aryl bromides." J Org Chem 69(9): 3236-3239.
Seo, J. B., et al. (2004). "Activated liver X receptors stimulate adipocyte differentiation through induction of peroxisome proliferator-activated receptor gamma expression." Mol Cell Biol 24(8): 3430-3444.

Question 20

2003

Accepted Answer

Kim, S. W., et al. (2003). "Activating signal cointegrator 2 required for liver lipid metabolism mediated by liver X receptors in mice." Mol Cell Biol 23(10): 3583-3592.
Wang, Y. X., et al. (2003). "Peroxisome-proliferator-activated receptor delta activates fat metabolism to prevent obesity." Cell 113(2): 159-170.
Jeong, H. J., et al. (2003). "Reduction in the toxicity of the dinoflagellate Gymnodinium catenatum when fed on by the heterotrophic dinoflagellate Polykrikos kofoidii" Aquatic microbial ecology31(3): 307-312.
Chawla, A., et al. (2003). "PPARdelta is a very low-density lipoprotein sensor in macrophages." Proc Natl Acad Sci U S A 100(3): 1268-1273.

Question 21

2002

Accepted Answer

Seo, Y. W., et al. (2002). "FOR, a novel orphan nuclear receptor related to farnesoid X receptor." J Biol Chem 277(20): 17836-17844.
Kim, S., et al. (2002). "Evaluation of morphogenic regulatory activity of farnesoic acid and its derivatives against Candida albicans dimorphism." Bioorg Med Chem Lett 12(6): 895-898.
Lee, M. O., et al. (2002). "Radicicol represses the transcriptional function of the estrogen receptor by suppressing the stabilization of the receptor by heat shock protein 90." Mol Cell Endocrinol 188(1-2): 47-54.
Ham, J. Y., et al. (2002). "A novel cytotoxic alkaloid of lamellarin class from a marine ascidian Didemnum sp." Bulletin of the Korean Chemical Society 23(1): 163-166.

Question 22

2001

Accepted Answer

Kim, Y. S., et al. (2001). "The orphan nuclear receptor small heterodimer partner as a novel coregulator of nuclear factor-kappa b in oxidized low density lipoprotein-treated macrophage cell line RAW 264.7." J Biol Chem 276(36): 33736-33740.
Jeong, H. J., et al. (2001). "Interactions among the toxic dinoflagellate Amphidinium carterae, the heterotrophic dinoflagellate Oxyrrhis marina, and the calanoid copepods Acartia spp." Marine Ecology Progress Series 218: 77-86.
Kim, Y. S., et al. (2001). "The orphan nuclear receptor SHP, as a novel coregulator of nuclear factor-kB in oxLDL-treated macrophage cell RAW 264.7" Journal of Biological Chemistry.
Jang, M. K., et al. (2001). "Ca2+/calmodulin-dependent protein kinase IV stimulates nuclear factor-kappa B transactivation via phosphorylation of the p65 subunit." J Biol Chem 276(23): 20005-20010.
Kim, Y. S., et al. (2001). "GENES: STRUCTURE AND REGULATION-The orphan nuclear receptor small heterodimer partner as a novel coregulator of nuclear factor-kB in oxidized low density lipoprotein-treated macrophage cell line" J Biol Chem 276(36): 33736-33740.
Kim, S. H., et al. (2001). "Efficient syntheses of 2-carbomethoxy-3, 4-disubstituted pyrroles by the condensation of vinylogous amides with aminomalonate" Bulletin of the Korean Chemical Society 22(12): 1403-1406.
Oh, K. B., et al. (2001). "Detection of antifungal activity in Belamcanda chinensis by a single-cell bioassay method and isolation of its active compound, tectorigenin." Biosci Biotechnol Biochem 65(4): 939-942.

Question 23

1998

Accepted Answer

Blumberg, B., et al. (1998). "BXR, an embryonic orphan nuclear receptor activated by a novel class of endogenous benzoate metabolites." Genes Dev 12(9): 1269-1277.

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